Horatio and Delko search Miami to bring down the Mala Noche gang once and for all after the murder of someone very close to them. However, their quest is jeopardized when the Feds seize the CSI lab with the intent to close it for good, based on the tip from the mole inside. When the mole is finally revealed to the entire lab, as well as the murder of an officer familiar to Delko, Caine and Wolfe the news sends the remaining CSIs reeling.





The Mala Noche gang trial is obstructed when the defendant goes free with the help of the witness who is testifying. When a hit ordered by the Mala Noche gang on Horatio finds the people he loves lives are in danger. Delko finds that an ex-lover is disturbing any woman who he is now close too.





During an A-list party, an heiress is found murdered in her own bathtub. The list of suspects includes her musician boyfriend, her assistant and her rival. Delko learns that Horatio and Marisol are going to be married very soon but mitigating circumstances may ruin their wedding.





A cruise ship that is docked in Miami is the scene for a double murder. The team investigates the long list of potential suspects but soon find that the list is dramatically decreased when the CSI’s find a large amount of money is missing from the victim’s stateroom. Horatio and Marisol’s relationship evolves.





The CSI team must locate a woman who has been kidnapped and dialed a wrong number on her cell phone. To try and find the woman the team must first figure out whom the kidnapped woman was trying to call in the first place. Marisol has a difficult decision to make and Horatio helps her. Natalia is surprised when Ryan asks for Delko’s permission to take her out on a date.





The CSI team must try to find out who is trying to kill a young couple (introduced in episode 86) who are released from prison. The couple was made out to be “media darlings” and soon find that not everyone though of them as darlings. Calleigh must work with her ex-possible-boyfriend to help solve the case.





After a group of wealthy women are robbed at a luxury day spa, evidence leads the CSIs to believe that this is a part of a much larger car chopping scam and each of these women are being targeted for a home robbery. Matters become worse when Horatio discovers that Marisol was also at the spa during the robbery and he must now protect her when her life is threatened. Meanwhile, Ryan must deal with the fallout after he freezes during a shootout.





The Miami-Dade district attorney loses a highly publicized murder trial in which a husband is accused of killing his young bride and then dumping her body in a lake. However, the woman’s body is recovered from a lake after the trial concludes and the ‘double jeopardy’ clause precludes the husband from being tried again. Now, as the CSIs fear that justice may not be served, new evidence suggests that the husband may have practiced on another victim first.





What appears to have been a horrible car accident claims the life of a woman. The evidence turns up more information and another body. During this intense murder investigation Natalia must confess a secret in order for the case to be solved.





Alexx’s DNA is found throughout her neighborhood where she is suspected to be responsible for the death of a convicted child molester. The CSI team soon learns that the mindset of the neighborhood could lead to any of the community wanting the man gone. The team must find out who the real killer was to clear Alexx.